SH2B3
SH2B3 (SH2B adapter protein 3) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Colorectal cancer, Myeloproliferative neoplasms, Endometrial cancer and 4 more. This dossier gathers the 0 products (0 approved), 0 trials, 0 pathways and 0 resistance routes in the corpus that involve it, with external identifiers so it can be joined to UniProt, ChEMBL, Open Targets and the rest of biology.
Biology
Links T-cell receptor activation signal to phospholipase C-gamma-1, GRB2 and phosphatidylinositol 3-kinase. Locus 12q24.12 (HGNC).
- Colorectal cancer: Open Targets association 0.63 with colorectal cancer (MONDO_0005575); CIViC evidence names this disease
- Myeloproliferative neoplasms: Open Targets association 0.61 with myeloproliferative neoplasm (MONDO_0020076)
- Endometrial cancer: Open Targets association 0.59 with endometrial cancer (MONDO_0011962)
- Myelodysplastic syndromes / neoplasms: IntOGen driver in 1 cohort (MDS)
- Leukaemia: Open Targets association 0.57 with leukaemia (MONDO_0005059)
- Sarcomas: Open Targets association 0.54 with sarcoma (MONDO_0005089)
External identifiers
Built from HGNC, Ensembl, UniProt and ChEMBL idsProducts by modality and phase
Browse products →No product in the corpus is aimed at this target yet.
Trials
Evidence ranking →No trial in the corpus names this target or one of its products.
Resistance routes
Unaddressed routes →The resistance atlas has no route that names this target.
Pathways
Pathway-to-drug matrix →No pathway diagram carries this target as a node.
Companion diagnostics
Assay registry →No companion diagnostic in the registry measures this target.
Preclinical models
All models →No model entry for this target yet; check the cancer entries on the models page.
Open questions
All open questions →No open questions recorded for this target yet. Suggest one.
Literature
Preprints →Query for this target: (TITLE:"SH2B3" OR ABSTRACT:"SH2B3" OR TITLE:"SH2B adaptor protein 3" OR ABSTRACT:"SH2B adaptor protein 3" OR TITLE:"SH2B adapter protein 3" OR ABSTRACT:"SH2B adapter protein 3" OR TITLE:"IDDM20" OR ABSTRACT:"IDDM20") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about SH2B3, not a curated reading list.
Export
The dossier as machine-readable JSON: identifiers from HGNC, Ensembl, UniProt and ChEMBL, products with status, trials, pathways, hotspots, open questions and assays. The full entity record is in the open API at /api/v1/entities/sh2b3.json. Licence CC BY-NC 4.0.