STAG2
STAG2 (Cohesin subunit SA-2) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a drug target, a tumour suppressor and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Bladder & urothelial cancer, Sarcomas, Renal cell carcinoma and 5 more. This dossier gathers the 0 products (0 approved), 0 trials, 0 pathways and 0 resistance routes in the corpus that involve it, with external identifiers so it can be joined to UniProt, ChEMBL, Open Targets and the rest of biology.
Biology
Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis. Location: Nucleus; Chromosome; Chromosome, centromere (UniProt). Locus Xq25 (HGNC).
- Bladder & urothelial cancer: Open Targets association 0.66 with urinary bladder cancer (MONDO_0001187); CIViC evidence names this disease
- Sarcomas: Open Targets association 0.62 with sarcoma (MONDO_0005089)
- Renal cell carcinoma: IntOGen driver in 2 cohorts (CCRCC, PRCC)
- Endometrial cancer: Open Targets association 0.52 with endometrial cancer (MONDO_0011962); IntOGen driver in 1 cohort (UCEC)
- Thyroid cancer: IntOGen driver in 1 cohort (WDTC)
- Breast cancer: Open Targets association 0.55 with breast cancer (MONDO_0007254)
External identifiers
Built from HGNC, Ensembl, UniProt and ChEMBL idsProducts by modality and phase
Browse products →No product in the corpus is aimed at this target yet.
Trials
Evidence ranking →No trial in the corpus names this target or one of its products.
Resistance routes
Unaddressed routes →The resistance atlas has no route that names this target.
Pathways
Pathway-to-drug matrix →No pathway diagram carries this target as a node.
Companion diagnostics
Assay registry →No companion diagnostic in the registry measures this target.
Preclinical models
All models →No model entry for this target yet; check the cancer entries on the models page.
Open questions
All open questions →No open questions recorded for this target yet. Suggest one.
Literature
Preprints →Query for this target: (TITLE:"STAG2" OR ABSTRACT:"STAG2" OR TITLE:"STAG2 cohesin complex component" OR ABSTRACT:"STAG2 cohesin complex component" OR TITLE:"Cohesin subunit SA-2" OR ABSTRACT:"Cohesin subunit SA-2" OR TITLE:"SA-2" OR ABSTRACT:"SA-2" OR TITLE:"SCC3B" OR ABSTRACT:"SCC3B" OR TITLE:"SA2" OR ABSTRACT:"SA2") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about STAG2, not a curated reading list.
Export
The dossier as machine-readable JSON: identifiers from HGNC, Ensembl, UniProt and ChEMBL, products with status, trials, pathways, hotspots, open questions and assays. The full entity record is in the open API at /api/v1/entities/stag2.json. Licence CC BY-NC 4.0.