Tryptophan hydroxylase 1
Tryptophan hydroxylase makes serotonin, the hormone that neuroendocrine tumours pour out in carcinoid syndrome; telotristat ethyl blocks the enzyme to cut the diarrhoea that somatostatin analogues leave uncontrolled. This dossier gathers the 0 products (0 approved), 0 trials, 0 pathways and 0 resistance routes in the corpus that involve it, with external identifiers so it can be joined to UniProt, ChEMBL, Open Targets and the rest of biology.
Biology
A cytosolic aromatic amino-acid hydroxylase requiring tetrahydrobiopterin and iron; converts tryptophan to 5-hydroxytryptophan, which is then decarboxylated to serotonin.
- Enterochromaffin cells of the gut and pineal gland
- Serotonin-secreting neuroendocrine tumours
External identifiers
Built from HGNC, Ensembl, UniProt and ChEMBL idsProducts by modality and phase
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Trials
Evidence ranking →No trial in the corpus names this target or one of its products.
Resistance routes
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Pathways
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Companion diagnostics
Assay registry →No companion diagnostic in the registry measures this target.
Preclinical models
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Open questions
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Literature
Preprints →Query for this target: (TITLE:"Tryptophan hydroxylase 1" OR ABSTRACT:"Tryptophan hydroxylase 1" OR TITLE:"TPH1" OR ABSTRACT:"TPH1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Tryptophan hydroxylase 1, not a curated reading list.
Export
The dossier as machine-readable JSON: identifiers from HGNC, Ensembl, UniProt and ChEMBL, products with status, trials, pathways, hotspots, open questions and assays. The full entity record is in the open API at /api/v1/entities/tph1.json. Licence CC BY-NC 4.0.