TUBB8
TUBB8 (Tubulin beta-8 chain) is a gene. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. Tied to Breast cancer, Lung cancer, Non-Hodgkin lymphoma and 5 more. This dossier gathers the 0 products (0 approved), 0 trials, 0 pathways and 0 resistance routes in the corpus that involve it, with external identifiers so it can be joined to UniProt, ChEMBL, Open Targets and the rest of biology.
Biology
Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilising cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. TUBB8 has a key role in meiotic spindle assembly and oocyte maturation. Location: Cytoplasm, cytoskeleton; Cytoplasm, cytoskeleton, spindle (UniProt). Locus 10p15.3 (HGNC).
- Breast cancer: Open Targets association 0.61 with breast cancer (MONDO_0007254)
- Lung cancer: Open Targets association 0.60 with lung cancer (MONDO_0008903)
- Non-Hodgkin lymphoma: Open Targets association 0.59 with non-Hodgkin lymphoma (MONDO_0018908)
- Prostate cancer: Open Targets association 0.59 with prostate cancer (MONDO_0008315)
- Hodgkin lymphoma: Open Targets association 0.59 with Hodgkins lymphoma (MONDO_0004952)
- Cervical cancer: Open Targets association 0.58 with cervical cancer (MONDO_0002974)
External identifiers
Built from HGNC, Ensembl, UniProt and ChEMBL idsProducts by modality and phase
Browse products →No product in the corpus is aimed at this target yet.
Trials
Evidence ranking →No trial in the corpus names this target or one of its products.
Resistance routes
Unaddressed routes →The resistance atlas has no route that names this target.
Pathways
Pathway-to-drug matrix →No pathway diagram carries this target as a node.
Companion diagnostics
Assay registry →No companion diagnostic in the registry measures this target.
Preclinical models
All models →No model entry for this target yet; check the cancer entries on the models page.
Open questions
All open questions →No open questions recorded for this target yet. Suggest one.
Literature
Preprints →Query for this target: (TITLE:"TUBB8" OR ABSTRACT:"TUBB8" OR TITLE:"tubulin beta 8 class VIII" OR ABSTRACT:"tubulin beta 8 class VIII" OR TITLE:"Tubulin beta-8 chain" OR ABSTRACT:"Tubulin beta-8 chain" OR TITLE:"bA631M21.2" OR ABSTRACT:"bA631M21.2") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about TUBB8, not a curated reading list.
Export
The dossier as machine-readable JSON: identifiers from HGNC, Ensembl, UniProt and ChEMBL, products with status, trials, pathways, hotspots, open questions and assays. The full entity record is in the open API at /api/v1/entities/tubb8.json. Licence CC BY-NC 4.0.