U2AF1
U2AF1 (Splicing factor U2AF 35 kDa subunit) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Myeloproliferative neoplasms, Leukaemia, Lung cancer and 5 more. This dossier gathers the 0 products (0 approved), 0 trials, 0 pathways and 0 resistance routes in the corpus that involve it, with external identifiers so it can be joined to UniProt, ChEMBL, Open Targets and the rest of biology.
Biology
Plays a critical role in both constitutive and enhancer-dependent splicing by mediating protein-protein interactions and protein-RNA interactions required for accurate 3'-splice site selection. Recruits U2 snRNP to the branch point. Directly mediates interactions between U2AF2 and proteins bound to the enhancers and thus may function as a bridge between U2AF2 and the enhancer complex to recruit it to the adjacent intron. Location: Nucleus; Nucleus speckle (UniProt). Locus 21q22.3 (HGNC).
- Myeloproliferative neoplasms: Open Targets association 0.70 with myeloproliferative neoplasm (MONDO_0020076)
- Leukaemia: Open Targets association 0.70 with leukaemia (MONDO_0005059)
- Lung cancer: Open Targets association 0.64 with lung cancer (MONDO_0008903)
- Pancreatic ductal adenocarcinoma: IntOGen driver in 4 cohorts (PAAD)
- Myelodysplastic syndromes / neoplasms: CIViC evidence names this disease
- Prostate cancer: IntOGen driver in 1 cohort (PRAD)
External identifiers
Built from HGNC, Ensembl, UniProt and ChEMBL idsProducts by modality and phase
Browse products →No product in the corpus is aimed at this target yet.
Trials
Evidence ranking →No trial in the corpus names this target or one of its products.
Resistance routes
Unaddressed routes →The resistance atlas has no route that names this target.
Pathways
Pathway-to-drug matrix →No pathway diagram carries this target as a node.
Companion diagnostics
Assay registry →No companion diagnostic in the registry measures this target.
Preclinical models
All models →No model entry for this target yet; check the cancer entries on the models page.
Open questions
All open questions →No open questions recorded for this target yet. Suggest one.
Literature
Preprints →Query for this target: (TITLE:"U2AF1" OR ABSTRACT:"U2AF1" OR TITLE:"U2 small nuclear RNA auxiliary factor 1" OR ABSTRACT:"U2 small nuclear RNA auxiliary factor 1" OR TITLE:"Splicing factor U2AF 35 kDa subunit" OR ABSTRACT:"Splicing factor U2AF 35 kDa subunit" OR TITLE:"U2AF35" OR ABSTRACT:"U2AF35" OR TITLE:"RNU2AF1" OR ABSTRACT:"RNU2AF1" OR TITLE:"U2AFBP" OR ABSTRACT:"U2AFBP") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about U2AF1, not a curated reading list.
Export
The dossier as machine-readable JSON: identifiers from HGNC, Ensembl, UniProt and ChEMBL, products with status, trials, pathways, hotspots, open questions and assays. The full entity record is in the open API at /api/v1/entities/u2af1.json. Licence CC BY-NC 4.0.