ZFHX3
ZFHX3 (Zinc finger homeobox protein 3) is a protein that switches other genes on and off. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Prostate cancer, Endometrial cancer, Breast cancer and 5 more. This dossier gathers the 0 products (0 approved), 0 trials, 0 pathways and 0 resistance routes in the corpus that involve it, with external identifiers so it can be joined to UniProt, ChEMBL, Open Targets and the rest of biology.
Biology
Transcriptional regulator which can act as an activator or a repressor. Inhibits the enhancer element of the AFP gene by binding to its AT-rich core sequence. In concert with SMAD-dependent TGF-beta signalling can repress the transcription of AFP via its interaction with SMAD2/3. Regulates the circadian locomotor rhythms via transcriptional activation of neuropeptidergic genes which are essential for intercellular synchrony and rhythm amplitude in the suprachiasmatic nucleus (SCN) of the brain. Regulator of myoblasts differentiation through the binding to the AT-rich sequence of MYF6 promoter and promoter repression. Down-regulates the MUC5AC promoter in gastric cancer. Location: Nucleus; Cytoplasm (UniProt). Locus 16q22.2-q22.3 (HGNC).
- Prostate cancer: Open Targets association 0.67 with prostate cancer (MONDO_0008315); IntOGen driver in 3 cohorts (PRAD)
- Endometrial cancer: Open Targets association 0.59 with endometrial cancer (MONDO_0011962); IntOGen driver in 3 cohorts (UCEC)
- Breast cancer: Open Targets association 0.61 with breast cancer (MONDO_0007254); IntOGen driver in 2 cohorts (BRCA)
- Thyroid cancer: Open Targets association 0.50 with thyroid cancer (MONDO_0002108); IntOGen driver in 2 cohorts (WDTC)
- Hepatocellular carcinoma: IntOGen driver in 2 cohorts (HCC)
- Bladder & urothelial cancer: IntOGen driver in 1 cohort (BLCA)
External identifiers
Built from HGNC, Ensembl, UniProt and ChEMBL idsProducts by modality and phase
Browse products →No product in the corpus is aimed at this target yet.
Trials
Evidence ranking →No trial in the corpus names this target or one of its products.
Resistance routes
Unaddressed routes →The resistance atlas has no route that names this target.
Pathways
Pathway-to-drug matrix →No pathway diagram carries this target as a node.
Companion diagnostics
Assay registry →No companion diagnostic in the registry measures this target.
Preclinical models
All models →No model entry for this target yet; check the cancer entries on the models page.
Open questions
All open questions →No open questions recorded for this target yet. Suggest one.
Literature
Preprints →Query for this target: (TITLE:"ZFHX3" OR ABSTRACT:"ZFHX3" OR TITLE:"zinc finger homeobox 3" OR ABSTRACT:"zinc finger homeobox 3" OR TITLE:"Zinc finger homeobox protein 3" OR ABSTRACT:"Zinc finger homeobox protein 3" OR TITLE:"ZNF927" OR ABSTRACT:"ZNF927" OR TITLE:"FLJ26184" OR ABSTRACT:"FLJ26184" OR TITLE:"ATBF1" OR ABSTRACT:"ATBF1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about ZFHX3, not a curated reading list.
Export
The dossier as machine-readable JSON: identifiers from HGNC, Ensembl, UniProt and ChEMBL, products with status, trials, pathways, hotspots, open questions and assays. The full entity record is in the open API at /api/v1/entities/zfhx3.json. Licence CC BY-NC 4.0.