drugsTreatmentEstablished

Danazol

aka Danol

Danazol is an old hormone tablet, licensed for endometriosis, that can raise haemoglobin and platelets in myelofibrosis and bone marrow failure. It was the comparison treatment that momelotinib beat in the MOMENTUM trial.

Danazol is a synthetic androgen licensed since the 1970s for endometriosis, fibrocystic breast disease and hereditary angioedema. In haematology it is used off-label for the anaemia of myelofibrosis and myelodysplastic syndromes and for immune and aplastic cytopenias, where about a third of patients improve; it also lengthens telomeres in telomere-biology disorders.

In the phase 3 MOMENTUM trial in symptomatic, anaemic myelofibrosis previously treated with a JAK inhibitor, danazol was the active comparator: 25 percent of patients on momelotinib had their symptom score halve against 9 percent on danazol, and more became transfusion independent. Liver toxicity, virilisation and thrombosis limit its use. The primary myelofibrosis page names it among the treatments for anaemia.

See it in action

A weak androgen derived from ethisterone that stimulates erythropoiesis and thrombopoiesis, in part by raising telomerase activity in haematopoietic cells, and suppresses gonadotropins.

1. What happens next: the hormonal schematic

How hormonal therapy works, step by step · animated schematic, not to scale; chosen from the modality "Oral synthetic androgen (hormonal agent)"

Hormonal Therapy →

2. Step by step

auto-advancing · hover to pause

1.Danazol acts on its target, the hormone receptor or the enzyme that makes the hormone.

Modality

Oral synthetic androgen (hormonal agent)

Mechanism

A weak androgen derived from ethisterone that stimulates erythropoiesis and thrombopoiesis, in part by raising telomerase activity in haematopoietic cells, and suppresses gonadotropins.

Brand / code

Danocrine

Trials

top

Trials recruiting now

Recruiting trials near you · live from ClinicalTrials.gov

Danazol

intervention: Danazol

Open on ClinicalTrials.gov →

within

Country and place are remembered in this browser only. A postcode is sent to OpenStreetMap's Nominatim service to find coordinates when you press the button; nothing else leaves your device.