Synthetic hypericin
HyBryte is an ointment containing synthetic hypericin, the active pigment of St John's wort. Rubbed on patches of cutaneous T-cell lymphoma and switched on with ordinary visible light, it kills the lymphoma cells in the skin without ultraviolet light.
Overview
Synthetic hypericin (SGX301, HyBryte) is Soligenix's photodynamic therapy for early-stage cutaneous T-cell lymphoma (mycosis fungoides). The ointment is applied to lesions and, after a delay, the area is exposed to visible fluorescent light twice a week. Because activation uses visible rather than ultraviolet light, the treatment avoids the skin-cancer and ageing risks of long-term PUVA and narrow-band UVB.
The phase 3 FLASH trial reported in 2020 that significantly more patients had a treatment response after the first 6-week cycle than with placebo ointment, and responses increased with longer treatment. The FDA asked for a second confirmatory study before approval, and the confirmatory FLASH2 trial is under way. The cutaneous T-cell lymphoma page names it as the skin-directed treatment closest to approval.
- 690 nm light
- IR700 dye on antibody
- Membrane rupture
Hypericin, the pigment of St John's wort made synthetically, is applied to skin lesions and taken up by malignant T cells; visible light then activates it to generate reactive oxygen that kills the cells, without the ultraviolet exposure of PUVA.
1.Synthetic hypericin slips into a pocket on its target.
Trials
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Latest papers
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