Resolution ctDx FIRST
A blood test approved with adagrasib to find the KRAS G12C mutation in lung cancer when a tissue biopsy is not possible.
Overview
Agilent's Resolution ctDx FIRST was approved by the FDA in December 2022 alongside adagrasib as a liquid biopsy companion diagnostic for KRAS G12C-mutant non-small-cell lung cancer, with tumour-profiling claims for other lung cancer genes. It is the second liquid comprehensive genomic profiling test with a companion claim after Guardant360 CDx and FoundationOne Liquid CDx. As with all plasma tests, a negative result should be followed by tissue testing.
Approvals
| Region | Year | Indication |
|---|---|---|
| US | 2022 | Companion diagnostic for adagrasib in KRAS G12C-mutant NSCLC (plasma) |
Trials
topRecruiting now (live from ClinicalTrials.gov)
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Notes
top- What a result means: KRAS G12C detected in blood makes adagrasib or sotorasib an option after first-line treatment.
Latest papers
topQuery for this drug: (TITLE:"Resolution ctDx FIRST" OR ABSTRACT:"Resolution ctDx FIRST") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Resolution ctDx FIRST, not a curated reading list.
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