Samarium-153 lexidronam
Quadramet is a radioactive injection that travels to painful bone metastases and irradiates them from inside, relieving pain from prostate, breast and other cancers that have spread widely to bone.
Overview
Samarium-153 lexidronam was approved by the FDA in March 1997 and authorised in the EU in February 1998 for relief of pain in patients with confirmed osteoblastic metastatic bone lesions that take up technetium-labelled bisphosphonate on bone scan, on placebo-controlled trials in which most patients had pain relief within one to two weeks lasting for months. It and strontium-89 (Metastron) were the bone-pain radiopharmaceuticals of the 1990s; radium-223 (Xofigo), which extends survival in prostate cancer, and PSMA radioligands have since taken most of their role. A single intravenous dose is given; transient marrow suppression, with nadir at three to five weeks, is the main toxicity, and a pain flare can occur early. Distributed by Lantheus in the US and Curium in Europe.
Approvals
| Region | Year | Indication |
|---|---|---|
| US | 1997 | Relief of pain in patients with confirmed osteoblastic metastatic bone lesions that enhance on radionuclide bone scan |
| EU | 1998 | Relief of bone pain from multiple painful osteoblastic skeletal metastases (Quadramet) |
Trials
topRecruiting now (live from ClinicalTrials.gov)
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Latest papers
topQuery for this drug: (TITLE:"Samarium-153 lexidronam" OR ABSTRACT:"Samarium-153 lexidronam" OR TITLE:"Quadramet" OR ABSTRACT:"Quadramet" OR TITLE:"153Sm-EDTMP" OR ABSTRACT:"153Sm-EDTMP" OR TITLE:"Samarium Sm 153 lexidronam pentasodium" OR ABSTRACT:"Samarium Sm 153 lexidronam pentasodium") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Samarium-153 lexidronam, not a curated reading list.
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