Talc (intrapleural)
Sterile talc is puffed or instilled into the chest cavity after fluid is drained to make the lung stick to the chest wall, stopping cancer-related fluid (malignant pleural effusion) from building up again.
Overview
Sclerosol intrapleural aerosol was approved by the FDA in December 1997 and sterile talc powder in 2003 to decrease the recurrence of malignant pleural effusion in symptomatic patients after drainage; talc has been the most effective pleurodesis agent in comparative trials and meta-analyses for decades. Poudrage at thoracoscopy and bedside slurry through a chest drain give similar success (TAPPS trial), and indwelling pleural catheters, with or without talc instilled through them (IPC-PLUS), are the main alternative for patients with trapped lung or short prognosis. Graded, large-particle talc is used to avoid the acute respiratory distress syndrome reported with small-particle preparations. Fever and chest pain after the procedure are expected.
Approvals
| Region | Year | Indication |
|---|---|---|
| US | 1997 | Prevention of recurrence of malignant pleural effusion after drainage (Sclerosol aerosol; sterile powder 2003) |
Trials
topRecruiting now (live from ClinicalTrials.gov)
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Latest papers
topQuery for this drug: (TITLE:"Talc" OR ABSTRACT:"Talc" OR TITLE:"intrapleural" OR ABSTRACT:"intrapleural" OR TITLE:"Sclerosol" OR ABSTRACT:"Sclerosol" OR TITLE:"Sterile Talc Powder" OR ABSTRACT:"Sterile Talc Powder" OR TITLE:"Steritalc" OR ABSTRACT:"Steritalc" OR TITLE:"Talc slurry" OR ABSTRACT:"Talc slurry") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Talc (intrapleural), not a curated reading list.
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