OnCo
ideasIdea

Cut the nerve supply to tumours with old drugs

Nerves feed pancreatic, prostate, and other tumours. Beta-blockers and botulinum toxin are cheap, safe, and already in trials to see if severing that link slows cancer.

Propranolol reduced proliferation markers in window trials; denervation slowed gastric cancer in mice; perampanel targets glioma synapses; perineural invasion is a strong prognostic factor.

Hypothesis
Adding β-blockade (or local denervation) to standard therapy improves outcomes in tumours with high perineural invasion or adrenergic signature.
Rationale
Strong preclinical mechanism (Monje, Amit, Zahalka), epidemiologic signals for β-blocker users, low cost and toxicity.
What would test it
Randomised phase 2 of propranolol vs placebo added to standard therapy in resectable pancreatic cancer with perineural invasion, endpoint DFS; glioma trial of perampanel plus standard therapy with growth-rate endpoint.
Maturity
early clinical

Connected

8top

Pages like this

not linked directly; found by shared links