Use food effects to cut the dose and cost of oral drugs that absorb better with meals
Some cancer pills are absorbed several times better with food, but the label says take them fasting at a high dose. Taking a quarter of the dose with breakfast can give the same drug levels at a quarter of the price.
Randomised PK and non-inferiority trials of low-dose-with-food versus standard fasting dosing for oral agents with large positive food effects (abiraterone is the established example; others include several kinase inhibitors), followed by label changes and guideline adoption. Regulators accept PK-bridged non-inferiority; payers fund the trials because savings are immediate.
- Wrong doses · Most drug doses were chosen as the highest a person can tolerate, which is often more than they need.
- Prices and value · New cancer drugs routinely cost over $150,000 a year, often for months of benefit. Systems cannot afford them and patients go bankrupt.
Pages like this
not linked directly; found by shared links- IdeaPublicly funded dose-reduction trials of expensive approved drugs
Shares Wrong doses, Prices and value, Small-molecule kinase inhibitors.
- PairingAI pathology → androgen deprivation duration
Shares Androgen deprivation & AR pathway inhibitors, Prostate cancer.
- IdeaFactorial dose finding for drug combinations instead of full dose of everything
- IdeaDose adjustments driven by patients' own symptom reports, tested against clinician judgement
- IdeaRestore weight-based dosing and vial sharing for immunotherapy in the label
Shares Wrong doses, Prices and value.
- IdeaPublicly funded trials of lower and less frequent doses of expensive cancer drugs
Shares Wrong doses, Prices and value.
- IdeaAnalyse and dose by sex: women get more toxicity from many cancer drugs at the same dose
- IdeaCardiometabolic screening and treatment for survivors on long-term hormone therapy
Shares Androgen deprivation & AR pathway inhibitors, Prostate cancer.