Alert guidelines and trials when a paper they rely on is retracted
When a study is retracted, everything built on it should get a warning. Today, retracted cancer papers keep being cited and used for years.
Retracted papers continue to be cited, and guidelines or trial protocols that relied on them are rarely revisited. A service that maps retractions and expressions of concern (from Retraction Watch and publishers) onto the citation graph and notifies guideline bodies, trial registries and systematic reviews that cite the retracted work would close a loop that is currently open.
- Failures are hidden · Negative trials, failed drugs and abandoned programmes are rarely published, so the same mistakes are repeated.
- Preclinical results do not reproduce · Fewer than half of landmark cancer biology findings reproduce when someone else tries.
Pages like this
not linked directly; found by shared links- IdeaBounties for documented failed replications of high-impact findings
Shares A replication status badge on every cancer paper, visible in PubMed, Preclinical results do not reproduce, Failures are hidden.
- IdeaEvery cancer biology PhD begins with a funded replication of a published finding
Shares A replication status badge on every cancer paper, visible in PubMed, Preclinical results do not reproduce.
- IdeaA guideline fast track for repurposed drugs with phase 3 evidence but no manufacturer
Shares ESMO Clinical Practice Guidelines & MCBS, NCCN Guidelines.
- IdeaGuidelines list the open trials at every decision point, updated monthly
Shares ESMO Clinical Practice Guidelines & MCBS, NCCN Guidelines.
- IdeaA global ledger of negative results and failed compounds with mandatory deposition
Shares Preclinical results do not reproduce, Failures are hidden.
- IdeaLabel every biomarker claim with an evidence phase, like drugs
Shares ESMO Clinical Practice Guidelines & MCBS, NCCN Guidelines.
- IdeaPre-registration and results reporting for real-world cancer studies
Shares Preclinical results do not reproduce, Failures are hidden.
- IdeaLive guideline-concordance dashboards for every tumour board, generated from the record
Shares ESMO Clinical Practice Guidelines & MCBS, NCCN Guidelines.