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Midline catheters, longer drips in the upper arm, carry fewer bloodstream infections than PICCs and are being used for chemotherapy. No guideline read says whether drugs that damage tissue if they leak can safely go through one.
The gap. None of the guidelines read for the midline protocol (CDC 2011, ESMO 2015, the Japanese extravasation guideline 2024) says whether vesicant or irritant chemotherapy may be given through a midline; the INS Standards, which address infusate limits, could not be read. The Japanese extravasation guideline cites a case report of oxaliplatin extravasation from a midline.
The evidence so far. A prospective Japanese study of 59 patients given continuous fluorouracil through a midline reported no phlebitis and complications in 6.8% (abstract). Whether this extends to vesicants and to irritants such as oxaliplatin has not been studied in any source read.
Shares Peripherally inserted central catheters (PICC lines), Toxicity and quality of life are undervalued and the tags protocol-upgrade, upgrade:untested.
Shares Infusion pumps, ports, and ambulatory chemotherapy devices, Toxicity and quality of life are undervalued and the tags protocol-upgrade, upgrade:untested.
Shares Infusion pumps, ports, and ambulatory chemotherapy devices and the tags protocol-upgrade, upgrade:untested.
Shares Toxicity and quality of life are undervalued and the tags protocol-upgrade, upgrade:untested.
Shares Toxicity and quality of life are undervalued and the tags protocol-upgrade, upgrade:untested.
Shares the tags protocol-upgrade, upgrade:untested.
Shares the tags protocol-upgrade, upgrade:untested.
Shares the tags protocol-upgrade, upgrade:untested.
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