Yale University Open Data Access (YODA) Project
The Yale programme that acts as independent steward of clinical trial data from Johnson & Johnson and other sponsors, letting outside researchers re-analyse trials including oncology studies.
Founded in 2011 by Harlan Krumholz and Joseph Ross at Yale, the YODA Project pioneered independent, transparent sharing of participant-level clinical trial data: sponsors (Johnson & Johnson since 2014, with Medtronic and others) hand over data and clinical study reports, and YODA reviews researcher requests against pre-specified criteria, publishing decisions and resulting publications. Its holdings include Janssen oncology trials of abiraterone, daratumumab, ibrutinib and CAR-T, enabling re-analyses of subgroups, toxicity and endpoints. YODA's model influenced the ICMJE data-sharing statement requirements and sits alongside Vivli and Project Data Sphere as the main academic trial data-sharing infrastructure.
- Independent trial data stewardship for Johnson & Johnson and others
- Transparent request review and reporting
- Data-sharing policy research