Repurposing metformin for the prevention of cancer and cancer recurrence
Paper by Andrea DeCensi indexed on Europe PMC as PubMed record 28776080, in Diabetologia (2017), one of the most cited records naming an author with this name at E.O. Ospedali Galliera.
Overview
Multiple epidemiological studies have documented an association between metformin, used for treatment of type 2 diabetes, and reduced cancer incidence and mortality. Cell line models may not accurately reflect the effects of metformin in the clinical setting. Moreover, findings from animal model studies have been inconsistent, whilst those from more recent epidemiological studies have tempered the overall effect size. The purpose of this review is to examine metformin's chemopreventive potential by outlining relevant mechanisms of action, the most recent epidemiologic evidence, and recently completed and ongoing clinical trials. Although repurposing drugs with excellent safety profiles is an appealing strategy for cancer prevention and treatment in the adjuvant setting, there is no substitute for well-executed, large randomised clinical trials to define efficacy and determine the populations that are most likely to benefit from an intervention. Thus, enthusiasm remains for understanding the role of metformin in cancer through ongoing clinical research.
Indexed on Europe PMC as PubMed record 28776080 (DOI 10.1007/s00125-017-4372-6). Its author list gives "DeCensi A" with the affiliation "Division of Medical Oncology, Ente Ospedaliero Ospedali Galliera, Genoa, Italy", which names E.O. Ospedali Galliera; that is how the record was matched to Andrea DeCensi, and no figure has been checked by an editor.
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