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A review that works out how many genome copies a blood sample holds, and why very small tumour fractions run out of molecules to find.
A review of circulating tumour DNA in diagnostics. Its full text states that most studies cite cell-free DNA in normal individuals at 1 to 10 ng per mL (average 5 ng per mL), that 5 ng of DNA equates to approximately 1,500 genomes, and that when the tumour fraction falls below 0.01 per cent a 10 mL blood draw (4 mL of plasma) will likely not contain a single cancer genome at a given locus, so detection becomes impossible through sampling error alone.
The number of molecules in the tube, not the sequencer, sets the floor for any single-locus blood test; multi-locus tests escape it only by adding sites together.
Shares Cell-free DNA (cfDNA), Circulating tumour DNA (ctDNA), Liquid biopsy (ctDNA).
Shares Cell-free DNA (cfDNA), Circulating tumour DNA (ctDNA), Liquid biopsy (ctDNA).
Shares Naming which clone or phenotype is left after treatment, Cell-free DNA (cfDNA), Circulating tumour DNA (ctDNA), Liquid biopsy (ctDNA).
Shares Naming which clone or phenotype is left after treatment, Cell-free DNA (cfDNA), Circulating tumour DNA (ctDNA), Liquid biopsy (ctDNA).
Shares Naming which clone or phenotype is left after treatment, Cell-free DNA (cfDNA), Circulating tumour DNA (ctDNA), Liquid biopsy (ctDNA).
Shares Cell-free DNA (cfDNA), Circulating tumour DNA (ctDNA), Liquid biopsy (ctDNA).
Shares Naming which clone or phenotype is left after treatment, Cell-free DNA (cfDNA), Circulating tumour DNA (ctDNA), Liquid biopsy (ctDNA).
Shares Naming which clone or phenotype is left after treatment, Cell-free DNA (cfDNA), Circulating tumour DNA (ctDNA).
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