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A stool test that looks for cancer DNA as well as blood found 92 percent of cancers against 74 percent for the blood-only test, at the price of more false alarms. It is the trial behind Cologuard.
Imperiale, Ransohoff, Itzkowitz and colleagues compared a non-invasive multitarget stool DNA test with a faecal immunochemical test in people at average risk of colorectal cancer, all of whom also had a colonoscopy. The DNA test includes quantitative molecular assays for KRAS mutations, aberrant NDRG4 and BMP3 methylation and beta-actin, plus a haemoglobin immunoassay, with results generated by a logistic-regression algorithm; values of 183 or more counted as positive, and faecal immunochemical test values above 100 ng of haemoglobin per millilitre of buffer counted as positive. Tests were processed independently of the colonoscopy findings.
Of 9,989 evaluable participants, 65 (0.7 percent) had colorectal cancer and 757 (7.6 percent) had advanced precancerous lesions.
The first molecular stool test to reach approval, and the template for the blood tests that followed: more sensitive for cancer, much less specific, and still poor at the precancerous lesions that screening is supposed to remove.
Shares Randomised controlled trial of faecal-occult-blood screening for colorectal cancer (Nottingham), Faecal immunochemical test (FIT), Colorectal cancer screening (colonoscopy, FIT, stool DNA, blood), The hardest cancers are found late and the tag colorectal-evidence.
Shares Effect of colonoscopy screening on risks of colorectal cancer and related death (NordICC), Treat screening uptake, not test sensitivity, as the thing to optimise, and settle the age extension with a trial rather than a model, Colorectal cancer screening (colonoscopy, FIT, stool DNA, blood), The hardest cancers are found late and the tag colorectal-evidence.
Shares Effect of colonoscopy screening on risks of colorectal cancer and related death (NordICC), Colorectal cancer screening (colonoscopy, FIT, stool DNA, blood), The hardest cancers are found late, New England Journal of Medicine and the tag colorectal-evidence.
Shares Effect of colonoscopy screening on risks of colorectal cancer and related death (NordICC), Faecal immunochemical test (FIT), Colorectal cancer screening (colonoscopy, FIT, stool DNA, blood), The hardest cancers are found late and the tag colorectal-evidence.
Shares Treat screening uptake, not test sensitivity, as the thing to optimise, and settle the age extension with a trial rather than a model, Colorectal cancer screening (colonoscopy, FIT, stool DNA, blood), The hardest cancers are found late, Colorectal cancer and the tag colorectal-evidence.
Shares Faecal immunochemical test (FIT), Colorectal cancer screening (colonoscopy, FIT, stool DNA, blood), The hardest cancers are found late, Colorectal cancer and the tag colorectal-evidence.
Shares Colorectal cancer screening (colonoscopy, FIT, stool DNA, blood), The hardest cancers are found late, Colorectal cancer and the tag colorectal-evidence.
Shares Colorectal cancer screening (colonoscopy, FIT, stool DNA, blood), The hardest cancers are found late, Colorectal cancer and the tag colorectal-evidence.