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Two of 228 Japanese triple-negative breast cancers, under 1%, were MSI-high; both were aggressive basal-like tumours without BRCA-like features.
MSI in 228 TNBCs was evaluated with the Promega MSI Analysis System 1.2 (BAT-26, NR-21, BAT-25, MONO-27, NR-24) without normal tissue controls. 222 (97.4%) were stable, 4 (1.7%) MSI-low and 2 (0.9%) MSI-high; the two MSI-high tumours were nuclear grade 3, Ki-67 above 30%, basal-like and non-BRCA-like, with inconsistent TILs, CD8 and PD-L1.
Rare MSI-high TNBC exists and qualifies for tumour-agnostic pembrolizumab, so comprehensive genomic profiling should report MSI even though dedicated testing is low-yield.
Shares Mismatch repair proteins (MLH1, MSH2, MSH6, PMS2), MSI-high (microsatellite instability by PCR or sequencing), Microsatellite instability (MSI-H) / mismatch repair deficiency (dMMR), Triple-negative breast cancer (TNBC).
Shares Mismatch repair proteins (MLH1, MSH2, MSH6, PMS2), MSI-high (microsatellite instability by PCR or sequencing), Microsatellite instability (MSI-H) / mismatch repair deficiency (dMMR).
Shares Mismatch repair proteins (MLH1, MSH2, MSH6, PMS2), MSI-high (microsatellite instability by PCR or sequencing), Microsatellite instability (MSI-H) / mismatch repair deficiency (dMMR).
Shares Mismatch repair proteins (MLH1, MSH2, MSH6, PMS2), MSI-high (microsatellite instability by PCR or sequencing), Microsatellite instability (MSI-H) / mismatch repair deficiency (dMMR).
Shares Mismatch repair proteins (MLH1, MSH2, MSH6, PMS2), Microsatellite instability (MSI-H) / mismatch repair deficiency (dMMR).
Shares Mismatch repair proteins (MLH1, MSH2, MSH6, PMS2), MSI-high (microsatellite instability by PCR or sequencing), Microsatellite instability (MSI-H) / mismatch repair deficiency (dMMR), Triple-negative breast cancer (TNBC).
Shares MSI-high (microsatellite instability by PCR or sequencing), Triple-negative breast cancer (TNBC).
Shares Mismatch repair proteins (MLH1, MSH2, MSH6, PMS2), Microsatellite instability (MSI-H) / mismatch repair deficiency (dMMR).