Metastatic colonization by circulating tumour cells
Paper cited by two pathway pages and one idea page, indexed on Europe PMC as PubMed record 26791720 and published in Nature; the citing pages link this DOI, which is how the record was matched.
Overview
Metastasis is the main cause of death in people with cancer. To colonize distant organs, circulating tumour cells must overcome many obstacles through mechanisms that we are only now starting to understand. These include infiltrating distant tissue, evading immune defences, adapting to supportive niches, surviving as latent tumour-initiating seeds and eventually breaking out to replace the host tissue. They make metastasis a highly inefficient process. However, once metastases have been established, current treatments frequently fail to provide durable responses. An improved understanding of the mechanistic determinants of such colonization is needed to better prevent and treat metastatic cancer.
Indexed on Europe PMC as PubMed record 26791720 (DOI 10.1038/nature17038). Matched by DOI alone: two pathway pages and one idea page cite this DOI among their external links (the pages are listed under Related), and this page was written so that the citation resolves inside OnCo. No figure has been checked by an editor.
Two pathway pages and one idea page on OnCo cite this paper by its DOI; this record gives the citation a page of its own so a reader can follow it without leaving OnCo. Read the abstract above alongside the citing pages listed under Related; the record was created automatically from the Europe PMC entry and its figures have not been checked by hand.
- Matched to the citing OnCo records by DOI alone; the summary reproduces the Europe PMC abstract and no figure has been verified against the full paper.
Similar pages
not linked directly; found by shared links- TermDisseminated tumour cells (DTCs)
Shares What decides which disseminated cells ever colonise?, Intravasation & circulating tumour cells, The metastatic cascade.
- TermHallmark: activating invasion and metastasis
Shares Intravasation & circulating tumour cells, The metastatic cascade.
- PathwayThe pre-metastatic niche
Shares Intravasation & circulating tumour cells, The metastatic cascade.
- PathwayTumour dormancy
Shares What decides which disseminated cells ever colonise?, The metastatic cascade.
- TermSeed and soil hypothesis of metastasis (Paget)
Shares Intravasation & circulating tumour cells, The metastatic cascade.
- InstitutionCold Spring Harbor Laboratory
Shares What decides which disseminated cells ever colonise?, The metastatic cascade.