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Pulling down DNA in blood that was still wrapped in the marks of active genes showed which genes the cells it came from were using.
Chromatin immunoprecipitation of cell-free nucleosomes carrying active chromatin modifications, followed by sequencing (cfChIP-seq), was applied to 268 human samples. In healthy donors it identified bone marrow megakaryocytes, but not erythroblasts, as major contributors to cell-free DNA; in liver disease it identified pathology-related changes in hepatocyte transcription; and in metastatic colorectal carcinoma it detected patient-specific information including transcriptionally active HER2 amplifications, at low sequencing depth.
The first demonstration that gene activity in the tissue of origin can be read from nucleosomes in blood.
Shares Plasma epigenomic profiling (cfChIP-seq), Cell-free DNA (cfDNA).
Shares Plasma epigenomic profiling (cfChIP-seq), Cell-free DNA (cfDNA).
Shares Plasma epigenomic profiling (cfChIP-seq), Cell-free DNA (cfDNA).
Shares Cell-free DNA (cfDNA), Colorectal cancer.
Shares Cell-free DNA (cfDNA), Colorectal cancer.
Shares Cell-free DNA (cfDNA), Colorectal cancer.
Shares Cell-free DNA (cfDNA), Colorectal cancer.
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