OnCo
pairingsPairing

Beta PRRT → alpha PRRT

When lutetium radioligand therapy stops working, alpha-emitting versions can still control the disease.

ALPHAMEDIX-02 PRRT-exposed cohort: ~83% progression-free at 18 months; ACTION-1 is the randomised test of 225Ac-DOTATATE after 177Lu.

Rationale
Alpha particles deliver oxygen-independent clustered DNA damage that beta-resistant clones cannot repair.
Evidence
Phase 2 (AlphaMedix); phase 3 pending (ACTION-1).

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