Micropapillary adenocarcinoma of the colon and rectum
Prepared with OnCo (onco.cc/prep/colorectal-micropapillary-carcinoma/). Orientation, not medical advice; your team knows your case.
My details
What I know, what is unclear, changes to discuss
Saved in this browserMy questions
8 on the sheet- 1.What is my exact diagnosis, stage, and grade, and which tests established them?
- 2.Which biomarkers have been tested on my tumour (for example Micropapillary component as a percentage of the tumour, recorded in the pathology report, Reversed polarity shown by villin, epithelial membrane antigen or E-cadherin staining, Lymphatic and vascular invasion, which travel with the pattern), and what were the results?
- 3.Which subtype is my cancer, and does that change the recommended treatment?
- 4.Is germline (inherited) genetic testing recommended for me or my family?
- 5.For my situation (localised disease), which of the standard options do you recommend and why?
- 6.Am I a candidate for CAPOX (capecitabine, oxaliplatin), FOLFOX (5-FU, leucovorin, oxaliplatin), and what side effects should I expect?
- 7.Would a second opinion at a high-volume centre change anything, and can you help arrange it?
- 8.What supportive care (symptom control, nutrition, exercise, mental health, financial help) is available from the start?
The words I may hear
- Total mesorectal excision (TME): The standard rectal cancer operation: the rectum is removed together with its surrounding fatty envelope (the mesorectum) in one intact package, which is where local recurrences used to come from.
- Circumferential resection margin (rectal cancer): The circumferential resection margin is the side surface of the removed rectum, the plane the surgeon cut along.
- TNM staging: TNM staging is the universal system describing tumour size (T), lymph node spread (N), and distant metastasis (M).
- Colectomy: Removing the part of the colon containing the cancer along with its blood supply and lymph nodes, then joining the ends.
- Grade: How abnormal the cancer cells look under the microscope, from grade 1 (close to normal, slow) to grade 3 or 4 (wildly abnormal, fast).
Tests and results to bring
Biomarker results to ask for: Micropapillary component as a percentage of the tumour, recorded in the pathology report, Reversed polarity shown by villin, epithelial membrane antigen or E-cadherin staining, Lymphatic and vascular invasion, which travel with the pattern.
Scans and tests linked to this cancer: Histopathology & immunohistochemistry.
Bring copies of scan reports, pathology and blood results, and a list of every medicine and supplement.
The treatments I may be offered
- Localised disease: Resection with the usual nodal harvest; adjuvant chemotherapy decided by stage as for colorectal adenocarcinoma of no special type, with the node involvement that travels with this pattern taken into account. (Colectomy, Total mesorectal excision (TME), CAPOX (capecitabine, oxaliplatin), FOLFOX (5-FU, leucovorin, oxaliplatin))
From the standard of care recorded for this cancer; which apply depends on your stage and biomarkers. Ask which the team recommends and why.