OnCo

Create your OnCo account

One account keeps your watchlist, saved views and cancer choice in sync across your devices, and lets OnCo alert you when a trial or treatment you follow changes. No password: we email you a sign-in link.

Account creation is being switched on. Until then, press Watch on any page and your list stays in this browser.

Living with cancer· Appointment prep

Appointment sheet: HER2-positive gastric cancer

One page to bring and write on: your details, the questions for HER2-positive gastric cancer plus your own, the words you may hear, what to bring, the treatments the standard of care names, and room for the answers and agreed next steps. What you type stays in this browser. Print it or save it as a PDF. New to all this? Start with the first 60 days. Orientation, not medical advice.

Tick the questions to print

All of this cancer's questions start ticked. Untick what does not apply; ticks are kept in this browser. .

Your own questions

Shared with the prep pack, so questions you add there appear here too.

Print or save as PDF

Use (or Ctrl+P, Cmd+P on a Mac). To keep a copy, choose Save as PDF as the destination in the print dialog. Only the sheet prints; the controls stay on screen. Your typed notes print where you typed them; empty fields print as ruled lines to write on.

Appointment sheet

HER2-positive gastric cancer

Prepared with OnCo (onco.cc/prep/gastric-her2-positive/). Orientation, not medical advice; your team knows your case.

My details

Name
Date of appointment
Hospital and clinician
Who is coming with me

What I know, what is unclear, changes to discuss

Saved in this browser
What I know so far
What is unclear to me
Changes since last time

My questions

20 on the sheet
Newly diagnosed
  1. 1.What is my exact diagnosis, stage, and grade, and which tests established them?
  2. 2.Which biomarkers have been tested on my tumour (for example HER2 by immunohistochemistry and in situ hybridisation, PD-L1 combined positive score, HER2 status on repeat biopsy at progression, ERBB2 amplification on plasma ctDNA), and what were the results?
  3. 3.Which subtype is my cancer, and does that change the recommended treatment?
  4. 4.Is germline (inherited) genetic testing recommended for me or my family?
Advanced, first line
  1. 5.For my situation (advanced, first line), which of the standard options do you recommend and why?
  2. 6.Am I a candidate for Trastuzumab, Pembrolizumab, Cisplatin or related drugs, and what side effects should I expect?
  3. 7.How do the results of ToGA apply to someone like me?
Second line
  1. 8.For my situation (second line), which of the standard options do you recommend and why?
  2. 9.Am I a candidate for Trastuzumab deruxtecan, Ramucirumab, Paclitaxel / nab-paclitaxel, and what side effects should I expect?
  3. 10.How do the results of DESTINY-Gastric04 apply to someone like me?
Later lines
  1. 11.For my situation (later lines), which of the standard options do you recommend and why?
  2. 12.Am I a candidate for Trifluridine/tipiracil, Zanidatamab, and what side effects should I expect?
  3. 13.How do the results of HERIZON-GEA-01 apply to someone like me?
Localised disease
  1. 14.For my situation (localised disease), which of the standard options do you recommend and why?
  2. 15.Am I a candidate for FLOT (5-FU, leucovorin, oxaliplatin, docetaxel), and what side effects should I expect?
Any stage
  1. 16.Are there clinical trials I could join, for example of Zanidatamab, HERIZON-GEA-01, Disitamab vedotin, HER2 sequence in gastric cancer: zanidatamab/trastuzumab + chemo ± PD-1 → T-DXd?
  2. 17.Would a second opinion at a high-volume centre change anything, and can you help arrange it?
  3. 18.What supportive care (symptom control, nutrition, exercise, mental health, financial help) is available from the start?
  4. 19.I read that “HER2 heterogeneity and loss after treatment make a single biopsy unreliable”. How does that affect my plan?
  5. 20.I read that “No HER2-directed therapy has yet improved cure rates in resectable disease”. How does that affect my plan?

The words I may hear

  • Gastrectomy: Removing part (subtotal) or all (total) of the stomach for stomach cancer, with the bowel joined to what remains.

Tests and results to bring

Biomarker results to ask for: HER2 by immunohistochemistry and in situ hybridisation (multiple biopsy sites), PD-L1 combined positive score (decides pembrolizumab in first line), HER2 status on repeat biopsy at progression, ERBB2 amplification on plasma ctDNA (trials).

Bring copies of scan reports, pathology and blood results, and a list of every medicine and supplement.

The treatments I may be offered

From the standard of care recorded for this cancer; which apply depends on your stage and biomarkers. Ask which the team recommends and why.

Answers and next steps

Saved in this browser
What I was told
Agreed next steps, dates and who to call