FLOT (5-FU, leucovorin, oxaliplatin, docetaxel)
FLOT is the four-drug chemotherapy given before and after surgery for stomach cancer in the West; since 2025 immunotherapy is added to it.
FLOT4-AIO (2019): perioperative FLOT beat ECF/ECX (OS 50 vs 35 months). MATTERHORN added durvalumab (OS HR 0.78; FDA approval November 2025). Four cycles before and four after gastrectomy. Neutropenia, neuropathy, and diarrhoea; tolerability limits use in frail patients, where FOLFOX or CAPOX substitute.
1.Docetaxel freezes the microtubule scaffold so cells cannot divide
- Route
- Intravenous
- Schedule
- Docetaxel 50 mg/m², oxaliplatin 85 mg/m², leucovorin 200 mg/m², 5-FU 2,600 mg/m² over 24 h, every 14 days; 4 cycles pre- and 4 post-operative
- Dose modifications
- G-CSF support commonly used; reduce for neuropathy or neutropenic fever
- Monitoring
- Blood counts, neuropathy, nutrition
| Adverse event |
|---|
| Neutropenia |
| Peripheral neuropathy |
| Diarrhoea, mucositis |
| Fatigue |
Common, including febrile neutropenia. Events listed without rates were not read from a primary source; see the label. Blank cells mean the figure was not sourced, not that it is zero.
Trials
topRecruiting now (live from ClinicalTrials.gov)
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Landmark trials in OnCo
Latest papers
topQuery for this drug: (TITLE:"FLOT" OR ABSTRACT:"FLOT" OR TITLE:"5-FU, leucovorin, oxaliplatin, docetaxel" OR ABSTRACT:"5-FU, leucovorin, oxaliplatin, docetaxel") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about FLOT (5-FU, leucovorin, oxaliplatin, docetaxel), not a curated reading list.
Pages like this
not linked directly; found by shared links- ProductOxaliplatin
Shares FLOT regimen (perioperative chemotherapy for gastric cancer), Platinum agents, Cytotoxic chemotherapy, Oesophageal cancer.
- ProductCAPOX (capecitabine, oxaliplatin)
Shares FOLFOX (5-FU, leucovorin, oxaliplatin), Platinum agents, Cytotoxic chemotherapy, Gastric & gastro-oesophageal junction cancer.
- ProductFluorouracil (5-FU)
Shares FLOT regimen (perioperative chemotherapy for gastric cancer), Cytotoxic chemotherapy, Oesophageal cancer, Gastric & gastro-oesophageal junction cancer.
- TrialCROSS
Shares Gastro-oesophageal junction (GEJ), Platinum agents, Cytotoxic chemotherapy, Oesophageal cancer.
- TermOesophagectomy
Shares Gastro-oesophageal junction (GEJ), Oesophageal cancer, Gastric & gastro-oesophageal junction cancer.
- TermBarrett's oesophagus (Barrett's metaplasia)
Shares Gastro-oesophageal junction (GEJ), Oesophageal cancer.
- IdeaUpfront reduced-dose regimens tested head-to-head in frail older patients
Shares Cytotoxic chemotherapy, Oesophageal cancer, Gastric & gastro-oesophageal junction cancer.
- ProductFOLFIRINOX / mFOLFIRINOX
Shares FOLFOX (5-FU, leucovorin, oxaliplatin), Platinum agents, Cytotoxic chemotherapy.