OnCo

Atezolizumab + bevacizumab

Checked 2026-09-09

Unresectable hepatocellular carcinoma, Child-Pugh A, varices treated

One cycle

every 21 days
178141521Atezolizumab: 1,200 mg, IntravenousAtezolizumabBevacizumab: 15 mg/kg, IntravenousBevacizumab
21-day cycle, until progressionIntravenous

Components

DrugDoseRouteDays
Atezolizumab
Monoclonal antibody (anti-PD-L1)
1,200 mgIVD1
Bevacizumab
Monoclonal antibody (anti-VEGF)
15 mg/kgIVD1
Cycles
until progression
21-day cycle
Emetogenicity
Minimal (<10%)
G-CSF
Not routine

Notes

  • Endoscopy for varices within 6 months before starting; bleeding risk with bevacizumab.

Used in

Source

IMbrave150, NEJM 2020

Reference doses for a typical adult from the cited protocol or label. Doses are adjusted for renal and hepatic function, age, performance status and prior toxicity, and institutional protocols vary. Verify against the current label and your local protocol before treating. Not medical advice.

Other regimens for these cancers