OnCo

STRIDE (tremelimumab + durvalumab)

Checked 2026-09-09

Unresectable hepatocellular carcinoma, first line

One cycle

every 28 days
1781415212228Tremelimumab: 300 mg single priming dose, IntravenousTremelimumabDurvalumab: 1,500 mg, IntravenousDurvalumab
28-day cycle, until progressionIntravenous

Components

DrugDoseRouteDays
Tremelimumab
Monoclonal antibody (anti-CTLA-4)
300 mg single priming doseIVD1
Durvalumab
Monoclonal antibody (anti-PD-L1)
1,500 mgIVD1
Cycles
until progression
28-day cycle
Emetogenicity
Minimal (<10%)
G-CSF
Not routine

Used in

Trials

Source

HIMALAYA, NEJM Evidence 2022

Reference doses for a typical adult from the cited protocol or label. Doses are adjusted for renal and hepatic function, age, performance status and prior toxicity, and institutional protocols vary. Verify against the current label and your local protocol before treating. Not medical advice.

Other regimens for these cancers