ATRA + arsenic trioxide
Checked 2026-09-09
Low or intermediate-risk acute promyelocytic leukaemia (WBC 10 × 10⁹/L or less)
One cycle
every 28 daysComponents
| Drug | Dose | Route | Days | Note |
|---|---|---|---|---|
Tretinoin (ATRA) Oral retinoid (differentiation agent) | 45 mg/m² per day in two doses | Oral | D1-28 | |
Arsenic trioxide Inorganic arsenical (differentiation agent) | 0.15 mg/kg per day | IV | D1-28 |
Cycles
induction until complete remission (up to 60 days), then 4 consolidation courses
28-day cycle
Emetogenicity
Minimal (<10%)
G-CSF
Not routine
Notes
- Differentiation syndrome: start dexamethasone 10 mg twice daily at the first sign; QTc and electrolytes with arsenic.
Used in
Source
Reference doses for a typical adult from the cited protocol or label. Doses are adjusted for renal and hepatic function, age, performance status and prior toxicity, and institutional protocols vary. Verify against the current label and your local protocol before treating. Not medical advice.