Everolimus
Checked 2026-09-09
Advanced progressive NET (RADIANT-3, RADIANT-4); RCC and HR-positive breast cancer after prior therapy
One cycle
every 28 daysComponents
| Drug | Dose | Route | Days | Note |
|---|---|---|---|---|
Everolimus Small-molecule mTOR inhibitor | 10 mg once daily | Oral | D1-28 |
Cycles
until progression
28-day cycle
Emetogenicity
Minimal (<10%)
G-CSF
Not routine
Notes
- Stomatitis is reduced by dexamethasone mouthwash prophylaxis (SWISH).
Used in
Trials
Products
Source
Reference doses for a typical adult from the cited protocol or label. Doses are adjusted for renal and hepatic function, age, performance status and prior toxicity, and institutional protocols vary. Verify against the current label and your local protocol before treating. Not medical advice.
Other regimens for these cancers
CAPTEM
Advanced pancreatic neuroendocrine tumour
every 28 days
177Lu-DOTATATE (PRRT)
SSTR-positive gastroenteropancreatic NET after somatostatin analogue
every 56 days × 4
Dose-dense AC → T
Node-positive or high-risk early breast cancer, adjuvant or neoadjuvant
every 14 days × 4
TC (docetaxel + cyclophosphamide)
Early breast cancer when an anthracycline is not wanted
every 21 days × 4
Trastuzumab deruxtecan 5.4 mg/kg
HER2-positive metastatic breast cancer second line; HER2-low or ultralow after chemotherapy or endocrine therapy; HER2-mutant NSCLC
every 21 days
Sacituzumab govitecan
Metastatic TNBC after two lines (one for metastatic disease); HR-positive after endocrine therapy and two chemotherapies
every 21 days
Capecitabine (post-neoadjuvant)
Residual invasive disease after neoadjuvant chemotherapy, HER2-negative
every 21 days × 6-8
Olaparib (adjuvant, OlympiA)
Germline BRCA1/2, HER2-negative, high-risk early breast cancer after chemotherapy
every 28 days × 13