OnCo

Nivolumab + ipilimumab (mesothelioma)

Checked 2026-09-09

Unresectable pleural mesothelioma first line, especially non-epithelioid

One cycle

every 42 days
178141521222829353642Nivolumab: 360 mg every 3 weeks, IntravenousNivolumabIpilimumab: 1 mg/kg every 6 weeks, IntravenousIpilimumab
42-day cycle, up to 2 yearsIntravenous

Components

DrugDoseRouteDays
Nivolumab
Monoclonal antibody (anti-PD-1)
360 mg every 3 weeksIVD1, 22
Ipilimumab
Monoclonal antibody (anti-CTLA-4)
1 mg/kg every 6 weeksIVD1
Cycles
up to 2 years
42-day cycle
Emetogenicity
Minimal (<10%)
G-CSF
Not routine

Used in

Source

CheckMate 743, Lancet 2021

Reference doses for a typical adult from the cited protocol or label. Doses are adjusted for renal and hepatic function, age, performance status and prior toxicity, and institutional protocols vary. Verify against the current label and your local protocol before treating. Not medical advice.

Other regimens for these cancers