VIP
Checked 2026-09-09
Poor-risk germ cell tumours first line when bleomycin is contraindicated, and salvage after BEP
Also called VIP (etoposide, ifosfamide, cisplatin).
One cycle
every 21 days × 4 · about 12 weeks in totalComponents
| Drug | Dose | Route | Days | Note |
|---|---|---|---|---|
Etoposide Topoisomerase II inhibitor (podophyllotoxin derivative) | 75 mg/m² | IV | D1-5 | |
Ifosfamide Cytotoxic chemotherapy (alkylating agent) | 1,200 mg/m² with mesna | IV | D1-5 | |
Cisplatin Cytotoxic chemotherapy (platinum) | 20 mg/m² | IV | D1-5 |
Cycles
4
21-day cycle
Emetogenicity
High (>90%)
G-CSF
Recommended
Notes
- Equivalent to BEP in poor-risk disease with more myelosuppression but no bleomycin lung toxicity.
Used in
Products
Source
Nichols (ECOG/SWOG), JCO 1998: VIP versus BEP in advanced disseminated germ cell tumours
Reference doses for a typical adult from the cited protocol or label. Doses are adjusted for renal and hepatic function, age, performance status and prior toxicity, and institutional protocols vary. Verify against the current label and your local protocol before treating. Not medical advice.