OnCo

Desmoid tumour: lines of therapy

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3 standard-of-care settings across 3 lines and 1 biomarker subgroup. Rows come from the cancer page's standard of care; the grid places each on its line and subgroup.

LineAll comers
Advanced, first line1
Second line1
Other settings1

Advanced, first line

SubgroupSettingApproachProducts and trialsEvidence
All comersNewly diagnosed, asymptomatic or minimally symptomaticActive surveillance with MRI at 1 to 2 months, then every 3 to 6 months; treat only on progression or symptoms.63

Second line

SubgroupSettingApproachProducts and trialsEvidence
All comersProgressive or symptomatic diseaseNirogacestat (DeFi) or sorafenib (Alliance A091105); alternatives include methotrexate-vinblastine, vinorelbine, anthracycline-based chemotherapy for rapidly progressive disease, and cryoablation for accessible extra-abdominal tumours.89

Other settings

SubgroupSettingApproachProducts and trialsEvidence
All comersSurgeryReserved for selected abdominal wall tumours or complications (bowel obstruction, fistula); margins do not reliably predict recurrence.40

Lines and subgroups are parsed from the setting text of each standard-of-care row and can misclassify an unusual phrasing; the row’s own setting is always shown. Guideline chips reflect the NCCN category and ESMO-MCBS grade recorded on the cancer page, checked on its stated date. Not medical advice.