Limb-salvage surgery and endoprosthetic reconstruction
Removing a bone or soft-tissue sarcoma while keeping the arm or leg, rebuilding with metal implants, bone grafts or growing prostheses in children.
Since the 1980s, >90% of extremity sarcomas are treated with limb-sparing resection plus radiotherapy (soft tissue) or chemotherapy (bone) with survival equal to amputation. Modular and expandable endoprostheses, allografts, rotationplasty, 3D-printed custom implants, and navigation-guided resection are current practice. Function and infection rates are the trade-offs.
How it works
Wide en-bloc resection with negative margins, reconstruction, and multimodal adjuvant therapy replace amputation.
- Preserves function without compromising survival
- Custom implants for pelvis and spine
- Implant infection and mechanical failure over decades
- Requires specialist sarcoma centres
Latest papers
topQuery for this technology: (TITLE:"Limb-salvage surgery and endoprosthetic reconstruction" OR ABSTRACT:"Limb-salvage surgery and endoprosthetic reconstruction") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Limb-salvage surgery and endoprosthetic reconstruction, not a curated reading list.
Pages like this
not linked directly; found by shared links- TermFNCLCC grade (soft-tissue sarcoma)
Shares Osteosarcoma, Rare and paediatric cancers without markets, Sarcomas (soft tissue, bone, GIST).
- PersonTerry Fox
Shares Osteosarcoma, Rare and paediatric cancers without markets, Sarcomas (soft tissue, bone, GIST).
- TermWide local excision
Shares Limb-salvage surgery, Sarcomas (soft tissue, bone, GIST).
- InstitutionNationwide Children's Hospital
Shares Ewing sarcoma, Osteosarcoma, Rare and paediatric cancers without markets.
- ProductDactinomycin (actinomycin D)
- CompanyPharmaMar
- InstitutionInstitut Bergonié
Shares Rare and paediatric cancers without markets, IMRT / IGRT (modern external beam), Sarcomas (soft tissue, bone, GIST).
- TechnologyHyperthermia
Shares Isolated limb perfusion and infusion, Sarcomas (soft tissue, bone, GIST).