FNCLCC grade (soft-tissue sarcoma)
The FNCLCC grade is a 1-to-3 score for soft-tissue sarcomas based on how abnormal, how fast-dividing, and how much dead tissue the tumour shows; grade drives whether chemotherapy is considered.
French Federation of Cancer Centres system: differentiation, mitotic count and necrosis summed to grade 1-3. Grade 3, size >5 cm and deep location define high-risk disease eligible for neoadjuvant chemotherapy (ISG-STS 1001) and for nomogram-based prediction (Sarculator).
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