Soft tissue and visceral sarcomas: ESMO-EURACAN-GENTURIS clinical practice guideline
The European sarcoma guideline sets out referral to reference centres, biopsy and molecular diagnosis, surgery with radiotherapy for localised disease, the selective use of chemotherapy, and histology-driven treatment of advanced disease.
Overview
Joint European guideline covering the diagnosis, staging, multidisciplinary management and follow-up of soft tissue and visceral sarcomas in adults, including limb and trunk sarcomas, retroperitoneal sarcoma, gastrointestinal stromal tumour, desmoid tumours and subtype-specific systemic therapy recommendations.
The general principles on the sarcoma subtype pages (reference centre surgery, radiotherapy for high-grade deep tumours, doxorubicin first line, histology-directed later lines) follow this guideline.
- Updated periodically; drug approvals since 2021 (for example nab-sirolimus, afamitresgene) are not covered.
Similar pages
not linked directly; found by shared links- Key paperEORTC 62012: doxorubicin alone versus intensified doxorubicin plus ifosfamide for first-line treatment of advanced soft tissue sarcoma
Shares Myxofibrosarcoma, Leiomyosarcoma, Malignant peripheral nerve sheath tumour (MPNST), Undifferentiated pleomorphic sarcoma (UPS).
- TermFNCLCC grade (soft-tissue sarcoma)
Shares Myxofibrosarcoma, Retroperitoneal sarcoma, Undifferentiated pleomorphic sarcoma (UPS), Soft tissue sarcoma of the extremity (localised and advanced).
- TrialSTRASS (EORTC 62092)
Shares Leiomyosarcoma, Liposarcoma, Retroperitoneal sarcoma.
- TreatmentTrabectedin
Shares Leiomyosarcoma, Liposarcoma, Retroperitoneal sarcoma, Undifferentiated pleomorphic sarcoma (UPS).
- TrialEORTC 62012
Shares Malignant peripheral nerve sheath tumour (MPNST), Undifferentiated pleomorphic sarcoma (UPS), Soft tissue sarcoma of the extremity (localised and advanced).
- Key paperLMS-04: doxorubicin plus trabectedin followed by trabectedin maintenance versus doxorubicin alone in metastatic leiomyosarcoma
Shares Leiomyosarcoma, Retroperitoneal sarcoma, Soft tissue sarcoma of the extremity (localised and advanced).
- Key paperFirst-line chemotherapy for malignant peripheral nerve sheath tumour versus other soft tissue sarcomas (EORTC pooled analysis)
Shares Malignant peripheral nerve sheath tumour (MPNST), Annals of Oncology.
- TrialLMS-04
Shares Leiomyosarcoma, Retroperitoneal sarcoma, Soft tissue sarcoma of the extremity (localised and advanced).