Tasonermin
Beromun is a recombinant form of the immune protein TNF-alpha, pumped with the chemotherapy melphalan through the isolated blood supply of an arm or leg to shrink soft-tissue sarcomas so that the limb can be saved rather than amputated.
Overview
Tasonermin was authorised by the European Commission in April 1999 as an adjunct to surgery for irresectable soft-tissue sarcoma of the limbs, with melphalan via mild hyperthermic isolated limb perfusion, to prevent or delay amputation or for palliation, on multicentre European studies in which the majority of patients achieved limb salvage. Systemic TNF-alpha is far too toxic to give intravenously, so the drug exists only for this surgical technique performed in a small number of specialist centres. It is not approved in the US. Regional toxicity (limb oedema, skin reactions, neuropathy) and, if leakage into the systemic circulation occurs, shock are the main risks; the same approach is used for in-transit melanoma.
Approvals
| Region | Year | Indication |
|---|---|---|
| EU | 1999 | Irresectable soft-tissue sarcoma of the limbs with melphalan via isolated limb perfusion, as an adjunct to surgery or for palliation |
Trials
topRecruiting now (live from ClinicalTrials.gov)
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Latest papers
topQuery for this drug: (TITLE:"Tasonermin" OR ABSTRACT:"Tasonermin" OR TITLE:"Beromun" OR ABSTRACT:"Beromun" OR TITLE:"Recombinant TNF-alpha-1a" OR ABSTRACT:"Recombinant TNF-alpha-1a" OR TITLE:"rTNF-alpha" OR ABSTRACT:"rTNF-alpha") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Tasonermin, not a curated reading list.
Pages like this
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