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Cancers & treatments·Sequencing

Localised penile cancer (organ-confined, node-negative): lines of therapy

Cancer page →

4 standard-of-care settings across 2 lines and 1 biomarker subgroup. Rows come from the cancer page's standard of care; the grid places each on its line and subgroup.

LineAll comers
Screening, prevention and diagnosis1
Other settings3

Screening, prevention and diagnosis

SubgroupSettingApproachProducts and trialsEvidence
All comersPreventionHPV vaccination (now offered to boys in many countries and being tested in Chinese men) and treatment of phimosis and lichen sclerosus.
HPV & HBV vaccinationNonavalent HPV vaccineA Phase III Study to Evaluate the Efficacy, Immunogenicity and Safety of the 9-valent HPV Vaccine in Chinese Males
86

Other settings

SubgroupSettingApproachProducts and trialsEvidence
All comersPenile intraepithelial neoplasiaCircumcision if the foreskin is involved; topical fluorouracil or imiquimod, laser ablation or glans resurfacing; close follow-up because recurrence is common.
Fluorouracil (5-FU)Thermal ablation and cryotherapy for cervical precancer
82
All comersT1 to T2 tumoursOrgan-sparing surgery (wide local excision, glansectomy, partial penectomy) with narrow margins; brachytherapy for small distal tumours; total penectomy only for large or proximal disease.
Mohs surgeryBrachytherapy
40
All comersClinically negative groinsSurveillance for low-risk tumours (Ta, T1 grade 1 without lymphovascular invasion); dynamic sentinel node biopsy for intermediate- and high-risk tumours, with inguinal lymphadenectomy if positive.
Sentinel lymph node biopsyLymphadenectomy (lymph node dissection)
68

Lines and subgroups are parsed from the setting text of each standard-of-care row and can misclassify an unusual phrasing; the row’s own setting is always shown. Guideline chips reflect the NCCN category and ESMO-MCBS grade recorded on the cancer page, checked on its stated date. Not medical advice.