OnCo

Waldenström macroglobulinaemia: lines of therapy

Cancer page →

3 standard-of-care settings across 3 lines and 1 biomarker subgroup. Rows come from the cancer page's standard of care; the grid places each on its line and subgroup.

LineAll comers
Advanced, first line1
Second line1
Other settings1

Advanced, first line

SubgroupSettingApproachProducts and trialsEvidence
All comersSymptomatic, first lineBendamustine-rituximab or dexamethasone-rituximab-cyclophosphamide for fixed duration; or zanubrutinib / ibrutinibrituximab) continuously; plasmapheresis first for hyperviscosity.87

Second line

SubgroupSettingApproachProducts and trialsEvidence
All comersRelapsedSwitch class (BTKi ↔ chemo-immunotherapy); bortezomib- or carfilzomib-based regimens; venetoclax; pirtobrutinib after covalent BTKi; autologous transplant in selected young patients.85

Other settings

SubgroupSettingApproachProducts and trialsEvidence
All comersAsymptomaticObservation; treat on symptoms, cytopenias, hyperviscosity or neuropathy, not on IgM level alone.63

Regimens in the library

Lines and subgroups are parsed from the setting text of each standard-of-care row and can misclassify an unusual phrasing; the row’s own setting is always shown. Guideline chips reflect the NCCN category and ESMO-MCBS grade recorded on the cancer page, checked on its stated date. Not medical advice.