mmr
No description yet: the sentence for this tag has not been written. 2 records carry it: 2 biomarkers.
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2 records
| Cancers | Other tags | ||||
|---|---|---|---|---|---|
dMMR (mismatch repair deficiency by IHC) MLH1, MSH2, MSH6, PMS2 dMMR means one of the four mismatch repair proteins is missing from the tumour cell nuclei on a stain. It is the tissue-level twin of MSI-high and opens checkpoint immunotherapy in endometrial, bowel and many other cancers. | Endometrial cancer, Mismatch-repair-deficient endometrial cancer, Colorectal cancer | none | biomarker | ||
MSI-high (microsatellite instability by PCR or sequencing) MLH1, MSH2, MSH6, PMS2 MSI-high means the tumour's DNA has unstable repeat sequences, the footprint of failed mismatch repair. It is measured by PCR or sequencing, gives the same answer as dMMR in most tumours, and unlocks the same immunotherapies. | Colorectal cancer, Endometrial cancer, Mismatch-repair-deficient endometrial cancer | none | biomarker |