ADAM29
ADAM29 (Disintegrin and metalloproteinase domain-containing protein 29) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Breast cancer.
Overview
May be involved in spermatogenesis and fertilisation. Seems to be a non catalytic metalloprotease-like protein.
Open Targets scores its association with cancer at 0.52 (direct and indirect evidence; datatypes literature 0.80, genetic association 0.65).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · ADAM29 (Disintegrin and metalloproteinase domain-containing protein 29) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Breast cancer.
- 1 · What it is
ADAM29 (Disintegrin and metalloproteinase domain-containing protein 29) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Breast cancer.
- 2 · What goes wrong in cancer
May be involved in spermatogenesis and fertilisation. Seems to be a non catalytic metalloprotease-like protein.
- 3 · How drugs use it
No product in this corpus aims at ADAM29 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
External identifiers
Sources: HGNC HGNC:207 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q9UKF5 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000168594 (association with cancer (MONDO_0004992) 0.52; per-cancer scores at or above 0.5: breast cancer 0.51 (GraphQL API, CC0))
Biology
May be involved in spermatogenesis and fertilisation. Seems to be a non catalytic metalloprotease-like protein. Location: Membrane (UniProt). Locus 4q34.1 (HGNC).
- Breast cancer: Open Targets association 0.51 with breast cancer (MONDO_0007254)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"ADAM29" OR ABSTRACT:"ADAM29" OR TITLE:"ADAM metallopeptidase domain 29" OR ABSTRACT:"ADAM metallopeptidase domain 29" OR TITLE:"Disintegrin and metalloproteinase domain-containing protein 29" OR ABSTRACT:"Disintegrin and metalloproteinase domain-containing protein 29" OR TITLE:"svph1" OR ABSTRACT:"svph1" OR TITLE:"CT73" OR ABSTRACT:"CT73") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about ADAM29, not a curated reading list.