APOBEC3B
APOBEC3B (DNA dC->dU-editing enzyme APOBEC-3B) is an enzyme. In the public catalogues the evidence so far is association rather than a proven role. Tied to Skin cancer.
Overview
DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome, along with a deamination-independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells.
Open Targets scores its association with cancer at 0.63 (direct and indirect evidence; datatypes literature 0.99, genetic association 0.24, somatic mutation 0.95).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · APOBEC3B (DNA dC->dU-editing enzyme APOBEC-3B) is an enzyme. In the public catalogues the evidence so far is association rather than a proven role. Tied to Skin cancer.
- 1 · What it is
APOBEC3B (DNA dC->dU-editing enzyme APOBEC-3B) is an enzyme. In the public catalogues the evidence so far is association rather than a proven role. Tied to Skin cancer.
- 2 · What goes wrong in cancer
DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms.
- 3 · How drugs use it
No product in this corpus aims at APOBEC3B yet. Inhibitors are shaped to fit the enzyme's active site so the reaction the cancer relies on stops.
External identifiers
Sources: HGNC HGNC:17352 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q9UH17 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000179750 (association with cancer (MONDO_0004992) 0.63; per-cancer scores at or above 0.5: skin cancer 0.50 (GraphQL API, CC0))
Biology
DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome, along with a deamination-independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells. Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single- or double-stranded RNA. Exhibits antiviral activity against simian immunodeficiency virus (SIV), hepatitis B virus (HBV) and human T-cell leukaemia virus type 1 (HTLV-1) and may inhibit the mobility of LTR and non-LTR retrotransposons. Location: Nucleus (UniProt). Locus 22q13.1 (HGNC).
- Skin cancer: Open Targets association 0.50 with skin cancer (MONDO_0002898)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"APOBEC3B" OR ABSTRACT:"APOBEC3B" OR TITLE:"apolipoprotein B mRNA editing enzyme catalytic subunit 3B" OR ABSTRACT:"apolipoprotein B mRNA editing enzyme catalytic subunit 3B" OR TITLE:"DNA dC->dU-editing enzyme APOBEC-3B" OR ABSTRACT:"DNA dC->dU-editing enzyme APOBEC-3B" OR TITLE:"PHRBNL" OR ABSTRACT:"PHRBNL" OR TITLE:"FLJ21201" OR ABSTRACT:"FLJ21201") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about APOBEC3B, not a curated reading list.