BMP4
BMP4 (Bone morphogenetic protein 4) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Colorectal cancer.
Overview
Growth factor of the TGF-beta superfamily that plays essential roles in many developmental processes, including neurogenesis, vascular development, angiogenesis and osteogenesis. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction. Initiates the canonical BMP signalling cascade by associating with type I receptor BMPR1A and type II receptor BMPR2.
Open Targets scores its association with cancer at 0.56 (direct and indirect evidence; datatypes literature 0.99, animal model 0.76, genetic association 0.68).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · BMP4 (Bone morphogenetic protein 4) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Colorectal cancer.
- 1 · What it is
BMP4 (Bone morphogenetic protein 4) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Colorectal cancer.
- 2 · What goes wrong in cancer
Growth factor of the TGF-beta superfamily that plays essential roles in many developmental processes, including neurogenesis, vascular development, angiogenesis and osteogenesis.
- 3 · How drugs use it
No product in this corpus aims at BMP4 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
External identifiers
Sources: HGNC HGNC:1071 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P12644 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000125378 (association with cancer (MONDO_0004992) 0.56; per-cancer scores at or above 0.5: colorectal cancer 0.54 (GraphQL API, CC0))
Biology
Growth factor of the TGF-beta superfamily that plays essential roles in many developmental processes, including neurogenesis, vascular development, angiogenesis and osteogenesis. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction. Initiates the canonical BMP signalling cascade by associating with type I receptor BMPR1A and type II receptor BMPR2. Once all three components are bound together in a complex at the cell surface, BMPR2 phosphorylates and activates BMPR1A. In turn, BMPR1A propagates signal by phosphorylating SMAD1/5/8 that travel to the nucleus and act as activators and repressors of transcription of target genes. Positively regulates the expression of odontogenic development regulator MSX1 via inducing the IPO7-mediated import of SMAD1 to the nucleus. Location: Secreted, extracellular space, extracellular matrix (UniProt). Locus 14q22.2 (HGNC).
- Colorectal cancer: Open Targets association 0.54 with colorectal cancer (MONDO_0005575)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"BMP4" OR ABSTRACT:"BMP4" OR TITLE:"bone morphogenetic protein 4" OR ABSTRACT:"bone morphogenetic protein 4" OR TITLE:"Bone morphogenetic protein 4" OR ABSTRACT:"Bone morphogenetic protein 4" OR TITLE:"BMP2B" OR ABSTRACT:"BMP2B") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about BMP4, not a curated reading list.