BTC
BTC (Probetacellulin) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
Overview
Growth factor that binds to EGFR, ERBB4 and other EGF receptor family members. Potent mitogen for retinal pigment epithelial cells and vascular smooth muscle cells.
Open Targets scores its association with cancer at 0.65 (direct and indirect evidence; datatypes literature 0.48, affected pathway 0.95, genetic association 0.35).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · BTC (Probetacellulin) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
- 1 · What it is
BTC (Probetacellulin) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
- 2 · What goes wrong in cancer
Growth factor that binds to EGFR, ERBB4 and other EGF receptor family members. Potent mitogen for retinal pigment epithelial cells and vascular smooth muscle cells.
- 3 · How drugs use it
No product in this corpus aims at BTC yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
External identifiers
Sources: HGNC HGNC:1121 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P35070 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000174808 (association with cancer (MONDO_0004992) 0.65; (GraphQL API, CC0))
Biology
Growth factor that binds to EGFR, ERBB4 and other EGF receptor family members. Potent mitogen for retinal pigment epithelial cells and vascular smooth muscle cells. Location: Secreted, extracellular space; Cell membrane (UniProt). Locus 4q13.3 (HGNC).
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"BTC" OR ABSTRACT:"BTC" OR TITLE:"betacellulin" OR ABSTRACT:"betacellulin" OR TITLE:"Probetacellulin" OR ABSTRACT:"Probetacellulin") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about BTC, not a curated reading list.