CACNA1H
CACNA1H (Voltage-dependent T-type calcium channel subunit alpha-1H) is a gene. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it.
Overview
Voltage-sensitive calcium channel that gives rise to T-type calcium currents. T-type calcium channels belong to the 'low-voltage activated (LVA)' group. A particularity of this type of channel is an opening at quite negative potentials, and a voltage-dependent inactivation.
Open Targets scores its association with cancer at 0.57 (direct and indirect evidence; datatypes clinical 0.87, literature 0.88, genetic association 0.00, somatic mutation 0.18, animal model 0.57).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · CACNA1H (Voltage-dependent T-type calcium channel subunit alpha-1H) is a gene. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it.
- 1 · What it is
CACNA1H (Voltage-dependent T-type calcium channel subunit alpha-1H) is a gene. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it.
- 2 · What goes wrong in cancer
Voltage-sensitive calcium channel that gives rise to T-type calcium currents. T-type calcium channels belong to the 'low-voltage activated (LVA)' group.
- 3 · How drugs use it
No product in this corpus aims at CACNA1H yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
External identifiers
Sources: HGNC HGNC:1395 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt O95180 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000196557 (association with cancer (MONDO_0004992) 0.57; (GraphQL API, CC0))
Biology
Voltage-sensitive calcium channel that gives rise to T-type calcium currents. T-type calcium channels belong to the 'low-voltage activated (LVA)' group. A particularity of this type of channel is an opening at quite negative potentials, and a voltage-dependent inactivation. T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signalling in secretory cells and vascular smooth muscle. They may also be involved in the modulation of firing patterns of neurons. In the adrenal zona glomerulosa, participates in the signalling pathway leading to aldosterone production in response to either AGT/angiotensin II, or hyperkalemia. Location: Cell membrane (UniProt). Locus 16p13.3 (HGNC).
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: Open Targets known-drug datatype score 0.87. Evidence tier "approved-drug" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"CACNA1H" OR ABSTRACT:"CACNA1H" OR TITLE:"calcium voltage-gated channel subunit alpha1 H" OR ABSTRACT:"calcium voltage-gated channel subunit alpha1 H" OR TITLE:"Voltage-dependent T-type calcium channel subunit alpha-1H" OR ABSTRACT:"Voltage-dependent T-type calcium channel subunit alpha-1H" OR TITLE:"Cav3.2" OR ABSTRACT:"Cav3.2") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about CACNA1H, not a curated reading list.