CCNH
CCNH (Cyclin-H) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role.
Overview
Component of the CDK-activating kinase (CAK) complex, a master regulator of CDK activity by catalysing the activating threonine phosphorylation of CDKs. Binds and activates cyclin-dependent protein kinase CDK7, the catalytic subunit of CAK. CAK activates major mediators of cell cycle control, including CDK1, CDK2, CDK4 and CDK6, and plays a key role in regulating cell cycle progression.
Open Targets scores its association with cancer at 0.53 (direct and indirect evidence; datatypes literature 0.92, genetic association 0.35, somatic mutation 0.74).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · CCNH (Cyclin-H) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role.
- 1 · What it is
CCNH (Cyclin-H) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role.
- 2 · What goes wrong in cancer
Component of the CDK-activating kinase (CAK) complex, a master regulator of CDK activity by catalysing the activating threonine phosphorylation of CDKs. Binds and activates cyclin-dependent protein kinase CDK7, the catalytic subunit of CAK.
- 3 · How drugs use it
No product in this corpus aims at CCNH yet. Transcription factors have no pocket to plug, so drugs either degrade them or block the partner protein they need to dock on DNA.
External identifiers
Sources: HGNC HGNC:1594 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P51946 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000134480 (association with cancer (MONDO_0004992) 0.53; (GraphQL API, CC0))
Biology
Component of the CDK-activating kinase (CAK) complex, a master regulator of CDK activity by catalysing the activating threonine phosphorylation of CDKs. Binds and activates cyclin-dependent protein kinase CDK7, the catalytic subunit of CAK. CAK activates major mediators of cell cycle control, including CDK1, CDK2, CDK4 and CDK6, and plays a key role in regulating cell cycle progression. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. Its expression and activity are constant throughout the cell cycle. Location: Nucleus (UniProt). Locus 5q14.3 (HGNC).
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"CCNH" OR ABSTRACT:"CCNH" OR TITLE:"cyclin H" OR ABSTRACT:"cyclin H" OR TITLE:"Cyclin-H" OR ABSTRACT:"Cyclin-H" OR TITLE:"p34" OR ABSTRACT:"p34" OR TITLE:"p37" OR ABSTRACT:"p37" OR TITLE:"CycH" OR ABSTRACT:"CycH") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about CCNH, not a curated reading list.