Cannabinoid receptor 1
The CB1 cannabinoid receptor is how dronabinol and nabilone, synthetic cannabinoids approved for chemotherapy nausea that other drugs fail to control, act on the brain; their place is behind the 5-HT3 and NK1 antagonists.
Overview
Cannabinoid receptor 1 is the brain receptor for THC and for the body's own endocannabinoids. Dronabinol (synthetic THC) and nabilone are approved for nausea and vomiting from chemotherapy in patients who have not responded to conventional antiemetics, and dronabinol also for appetite loss in AIDS; guidelines place them as later options after 5-HT3 antagonists, NK1 antagonists, dexamethasone and olanzapine because of dizziness, sedation and mood effects. Claims that cannabinoids shrink tumours rest on laboratory and small early studies, and no cannabinoid is approved to treat cancer itself.
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · The CB1 cannabinoid receptor is how dronabinol and nabilone, synthetic cannabinoids approved for chemotherapy nausea that other drugs fail to control, act on the brain; their place is behind the 5-HT3 and NK1 antagonists.
- 1 · What it is
The CB1 cannabinoid receptor is how dronabinol and nabilone, synthetic cannabinoids approved for chemotherapy nausea that other drugs fail to control, act on the brain; their place is behind the 5-HT3 and NK1 antagonists.
- 2 · What goes wrong in cancer
A Gi-coupled G-protein-coupled receptor, among the most abundant in the brain, that reduces neurotransmitter release from presynaptic terminals; also present in gut, fat and liver.
- 3 · How drugs use it
No product in this corpus aims at Cannabinoid receptor 1 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
External identifiers
Biology
A Gi-coupled G-protein-coupled receptor, among the most abundant in the brain, that reduces neurotransmitter release from presynaptic terminals; also present in gut, fat and liver.
- Brain, including the emetic circuitry of the brainstem
- Peripheral tissues and some tumour cells
Latest papers
topQuery for this target: (TITLE:"Cannabinoid receptor 1" OR ABSTRACT:"Cannabinoid receptor 1" OR TITLE:"CNR1" OR ABSTRACT:"CNR1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Cannabinoid receptor 1, not a curated reading list.