CUL1
CUL1 (Cullin-1) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
Overview
Core component of multiple cullin-RING-based SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. SCF complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins. In the SCF complex, serves as a rigid scaffold that organises the SKP1-F-box protein and RBX1 subunits.
Open Targets scores its association with cancer at 0.53 (direct and indirect evidence; datatypes literature 0.90, affected pathway 0.83, genetic association 0.00).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · CUL1 (Cullin-1) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
- 1 · What it is
CUL1 (Cullin-1) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
- 2 · What goes wrong in cancer
Core component of multiple cullin-RING-based SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription.
- 3 · How drugs use it
No product in this corpus aims at CUL1 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
External identifiers
Sources: HGNC HGNC:2551 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q13616 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000055130 (association with cancer (MONDO_0004992) 0.53; (GraphQL API, CC0))
Biology
Core component of multiple cullin-RING-based SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. SCF complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins. In the SCF complex, serves as a rigid scaffold that organises the SKP1-F-box protein and RBX1 subunits. May contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and exchange of the substrate recognition component is mediated by TIP120A/CAND1. The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component. Locus 7q36.1 (HGNC).
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"CUL1" OR ABSTRACT:"CUL1" OR TITLE:"cullin 1" OR ABSTRACT:"cullin 1" OR TITLE:"Cullin-1" OR ABSTRACT:"Cullin-1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about CUL1, not a curated reading list.