DCLRE1B
DCLRE1B (5' exonuclease Apollo) is an enzyme. The public catalogues list it as a DNA repair gene, and the evidence so far is association rather than a proven role.
Overview
5'-3' exonuclease that plays a central role in telomere maintenance and protection during S-phase. Participates in the protection of telomeres against non-homologous end-joining (NHEJ)-mediated repair, thereby ensuring that telomeres do not fuse. Plays a key role in telomeric loop (T loop) formation by being recruited by TERF2 at the leading end telomeres and by processing leading-end telomeres immediately after their replication via its exonuclease activity: generates 3' single-stranded overhang at the leading end telomeres avoiding blunt leading-end telomeres that are vulnerable to end-joining reactions and expose the telomere end in a manner that activates the DNA repair pathways.
Open Targets scores its association with cancer at 0.55 (direct and indirect evidence; datatypes literature 0.83, genetic association 0.70).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · DCLRE1B (5' exonuclease Apollo) is an enzyme. The public catalogues list it as a DNA repair gene, and the evidence so far is association rather than a proven role.
- 1 · What it is
DCLRE1B (5' exonuclease Apollo) is an enzyme. The public catalogues list it as a DNA repair gene, and the evidence so far is association rather than a proven role.
- 2 · What goes wrong in cancer
5'-3' exonuclease that plays a central role in telomere maintenance and protection during S-phase.
- 3 · How drugs use it
No product in this corpus aims at DCLRE1B yet. Inhibitors are shaped to fit the enzyme's active site so the reaction the cancer relies on stops.
External identifiers
Sources: HGNC HGNC:17641 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q9H816 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000118655 (association with cancer (MONDO_0004992) 0.55; (GraphQL API, CC0))
Biology
5'-3' exonuclease that plays a central role in telomere maintenance and protection during S-phase. Participates in the protection of telomeres against non-homologous end-joining (NHEJ)-mediated repair, thereby ensuring that telomeres do not fuse. Plays a key role in telomeric loop (T loop) formation by being recruited by TERF2 at the leading end telomeres and by processing leading-end telomeres immediately after their replication via its exonuclease activity: generates 3' single-stranded overhang at the leading end telomeres avoiding blunt leading-end telomeres that are vulnerable to end-joining reactions and expose the telomere end in a manner that activates the DNA repair pathways. Together with TERF2, required to protect telomeres from replicative damage during replication by controlling the amount of DNA topoisomerase (TOP1, TOP2A and TOP2B) needed for telomere replication during fork passage and prevent aberrant telomere topology. Also involved in response to DNA damage: plays a role in response to DNA interstrand cross-links (ICLs) by facilitating double-strand break formation. In case of spindle stress, involved in prophase checkpoint. Location: Chromosome, telomere; Nucleus; Cytoplasm, cytoskeleton, microtubule organizing center, centrosome (UniProt). Locus 1p13.2 (HGNC).
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: UniProt keyword "DNA repair". Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"DCLRE1B" OR ABSTRACT:"DCLRE1B" OR TITLE:"DNA cross-link repair 1B" OR ABSTRACT:"DNA cross-link repair 1B" OR TITLE:"5' exonuclease Apollo" OR ABSTRACT:"5' exonuclease Apollo" OR TITLE:"SNM1B" OR ABSTRACT:"SNM1B" OR TITLE:"FLJ12810" OR ABSTRACT:"FLJ12810" OR TITLE:"FLJ13998" OR ABSTRACT:"FLJ13998") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about DCLRE1B, not a curated reading list.