DNAH11
DNAH11 (Dynein axonemal heavy chain 11) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
Overview
Force generating protein required for cilia beating in respiratory epithelia. Produces force towards the minus ends of microtubules. Key component of dynein, a family of motor proteins essential for movement along microtubules.
Open Targets scores its association with cancer at 0.51 (direct and indirect evidence; datatypes literature 0.24, animal model 0.40, genetic association 0.66).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · DNAH11 (Dynein axonemal heavy chain 11) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
- 1 · What it is
DNAH11 (Dynein axonemal heavy chain 11) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
- 2 · What goes wrong in cancer
Force generating protein required for cilia beating in respiratory epithelia. Produces force towards the minus ends of microtubules.
- 3 · How drugs use it
No product in this corpus aims at DNAH11 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
External identifiers
Sources: HGNC HGNC:2942 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q96DT5 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000105877 (association with cancer (MONDO_0004992) 0.51; (GraphQL API, CC0))
Biology
Force generating protein required for cilia beating in respiratory epithelia. Produces force towards the minus ends of microtubules. Key component of dynein, a family of motor proteins essential for movement along microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Required for structural and functional integrity of cilia. Location: Cytoplasm, cytoskeleton, cilium axoneme (UniProt). Locus 7p15.3 (HGNC).
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"DNAH11" OR ABSTRACT:"DNAH11" OR TITLE:"dynein axonemal heavy chain 11" OR ABSTRACT:"dynein axonemal heavy chain 11" OR TITLE:"Dynein axonemal heavy chain 11" OR ABSTRACT:"Dynein axonemal heavy chain 11" OR TITLE:"Dnahc11" OR ABSTRACT:"Dnahc11" OR TITLE:"DPL11" OR ABSTRACT:"DPL11" OR TITLE:"CILD7" OR ABSTRACT:"CILD7") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about DNAH11, not a curated reading list.